Escasa prevalencia XMRV/MLV enfermos cáncer prostata Japón

[elipoarch]

[t]A PRELIMINARY SCREENING OF XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED
VIRUS IN JAPANESE PROSTATE CANCER PATIENTS[/t]
Tsukasa Igawa, Yoshinao Kubo, Katsura Kakoki, Naoki Yamamoto, Hideki Sakai
The Journal of Urology
Volume 185, Issue 4, Supplement , Page e510, April 2011

INTRODUCTION AND OBJECTIVES
Recently, a new gammaretrovirus, xenotropic murine leukemia
virus-related virus (XMRV), was detected in prostatic tissue in
patients with familial prostate cancer, specifically in patients
homozygous for a missense mutation in the RNase L gene, R462Q. More
recent report revealed that polytropic murine leukemia virus-related
virus (polytropic MLV) gene sequences were frequently detected in
chronic fatigue syndrome patient. These reports are mainly from
western countries, thus it is not clear that the actual prevalence of
XMRV or other types of MLV infection in Japanese male. Here, we
attempt to examine the infection status of MLV in Japanese with
prostate cancer.

METHODS
A total of 61 prostate biopsy specimens were used for this study. RNA
samples were prepared from these prostate biopsy tissues, and were
screened for the presence of MLV-specific env sequences using highly
sensitive RT and nested PCR approach.

RESULTS
MLV sequences were detected in four out of sixty one patients (6.7%).
Of these four positive cases, XMRV was detected in one. And in the
other three cases, polytropic MLV gene sequence was detected. The
clinical diagnosis of XMRV positive case was cT2bN0M0, Gleason score
4+4=8, PSA 20.7 ng/ml with no family history for prostate cancer.
Subsequently, blood sample from this patient was analyzed, however,
XMRV was not detected. Three polytropic MLV detected cases included 2
positive and one negative for prostate cancer.

CONCLUSIONS
Our results suggest relatively lower rate of existence for XMRV in
prostatic tissue of Japanese prostate cancer patients. In addition,
there also exists a possibility of polytropic MLV infection in
Japanese prostate cancer patients, and it may be the first report
regarding polytropic MLV gene sequence detection in Japanese male.

fuente: http://www.jurology.com/article/S0022-5347(11" onclick="window.open(this.href);return false;)01208-0/fulltext